Looks to me that the San Francisco 49ers’ defensive coordinator Robert Saleh will be tasked with the near impossible job of slowing down Kansas City quarterback Patrick Mahomes. He will have to put a game plan together from scratch as no other defensive coordinator in the league has come up with a consistent approach in this endeavor. Putting Mahomes under duress will be key for the 49ers if they’re to have a chance. With players like Tyreek Hill, Mecole Hardman, and Sammy Watkins tearing up the field with their blazing speed, this will be easier said than done. The 49ers are primarily a zone coverage team but they will need to mix it up against the Chiefs. If the 49ers run zone coverage too many times, pass-catcher Travis Kelse will pick the defense apart all day. The 49ers defense will need to try and give Mahomes one look when he’s expecting another to have any success. The 49ers offense will need to use their effective running game to limit the opportunities for Mahomes, as every chance he gets is another chance to take the game over. The 49ers pass-rush will be tested, but I believe they can pressure Mahomes enough to make a difference. My prediction is 49ers over the Chiefs 38-35.